While most distros can handle having both installed and switching between them, it will cause redundant apps and KDE’s font settings will bleed into gnome.

My recommendation is NixOS as it will take care of removing all packages that come with one DE before installing the other one.

But NixOs is pretty weird even for regular Linux users.

Not sure exactly what you’re referring to, but you can pretty much change everything about your keyboard layout with kmonad and keyd

Fr, accessibility is def important and they’re not giving it enough attention