Note at top of developer web site:

Distribution of Enhancer for YouTube™ temporarily stopped! Due to the countless changes that the YouTube developers have made, Enhancer for YouTube™ is now completely broken for Firefox (partially works for Chromium based browsers) so I had to pause its distribution.

So far I’ve found the Improve YouTube extension does many (but not all) of the things Enhancer did.

AppStream makes machine-readable software metadata easily accessible. It is a foundational block for modern Linux software centers, offering a seamless way to retrieve information about available software, no matter the repository it is contained in. It can provide data about available applications as well as available firmware, drivers, fonts and other components. This project it part of freedesktop.org.

Maybe check out Pop! OS

But, yes, nearly all linux software will run on any distro. And even a fair amount of windows software will run on any of them with WINE (or VirtualBox if desperate). Occasionally commercial software will get packaged in an “installer” format a particular distro doesn’t know how to install. A fairly rare situation, for which there are almost always work-arounds. You can cross that bridge if you ever encounter it.